Accession Number : ADA171868


Title :   An Osteoinductive Polymer Composite for Cranial and Maxillofacial Bone Repair,


Corporate Author : ARMY INST OF DENTAL RESEARCH WASHINGTON DC


Personal Author(s) : Schmitz,John P ; Hollinger,Jeffrey O


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a171868.pdf


Report Date : Jan 1985


Pagination or Media Count : 25


Abstract : A biodegradable copolymer of polylactide: polyglycolide (PLA:PGA) was combined with allogeneic decalcified freeze-dried bone (DFDB) and implanted into 15 mm diameter defects in the calvaria of 26 New Zealand White rabbits. Similar defects were created in the calvaria of another 26 rabbits. These animals served as controls and did not receive copolymer implants. Upon sacrifice, both the implants and the controls were evaluated clinically, radiographically, and histomorphometrically using a Zeiss Image Analysis System. Both controls and implants were evaluated in groups at 4, 8, 12, 16, 20, and 24 weeks. When compared with the control defects, the copolymer:DFDB composite implants displayed a significantly greater volume of trabecular bone (p0.025). Two of the 15 mm diameter defects completely healed at 8 weeks. No adverse host tissue responses were observed histologically.


Descriptors :   *POLYMERS , *COMPOSITE MATERIALS , *SURGICAL IMPLANTATION , *BONES , *ARTIFICIAL TISSUE , COPOLYMERS , COMPATIBILITY , HEALING , RABBITS , DEFECT ANALYSIS , MAXILLA , SKULL


Subject Categories : Medicine and Medical Research
      Medical Facilities, Equipment and Supplies
      Laminates and Composite Materials
      Plastics


Distribution Statement : APPROVED FOR PUBLIC RELEASE