Accession Number : ADA171737


Title :   Kinetics Modeling of Cancer Immunology.


Descriptive Note : Final rept.,


Corporate Author : NAVAL ACADEMY ANNAPOLIS MD


Personal Author(s) : Helmers,Scott W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a171737.pdf


Report Date : 09 May 1986


Pagination or Media Count : 64


Abstract : In the presence of antibody, some cancerous antigens have demonstrated a unique mechanism of immunological escape. The mechanism by which these tumors avoid immune destruction is to constantly change their antigen surface, thus preventing the immune system from effectively completing its response to a given antigen. The exact means by which these tumor cells change their antigen surface is unknown. In this study, a kinetics model for an immune response to such a system is presented. Comparisons between the model data and experimental data indicate similar response characteristics, e.g. amplitude, shape, and oscillation frequency of the cancer cell populations, thus lending credibility to the mathematical model. In addition, parameters of the model are varied to note the degree of sensitivity of the cancerous system, in order to achieve further meaningful results. Finally, concepts for a more rigorous model, including more intercellular interactions, are proposed.


Descriptors :   *MATHEMATICAL MODELS , *RESPONSE(BIOLOGY) , *ANTIGEN ANTIBODY REACTIONS , KINEMATICS , EXPERIMENTAL DATA , SHAPE , NEOPLASMS , AMPLITUDE , OSCILLATION , IMMUNOSUPPRESSION , CANCER


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE