Accession Number : ADA171081


Title :   Mean Platelet Volume as an Indicator of Platelet Rejuvenation Following Bone Marrow Transplantation.


Descriptive Note : Master's thesis,


Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH


Personal Author(s) : Seanger,Danny G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a171081.pdf


Report Date : Jul 1986


Pagination or Media Count : 185


Abstract : Thrombocytopenia of unpredictable duration and severity is an expected outcome of the radiation/chemotherapy protocols performed prior to bone marrow transplantation. Serial evaluation of the platelet count and mean platelet volume of patients diagnosed with acute leukemia demonstrated the mean platelet volume to increase into reference limits 24 to 40 hours prior to a rise in the platelet count in those patients whose bone marrow successfully responded to induction chemotherapy. Serial platelet counts and measurements of mean platelet volume were performed on 31 patients following bone marrow transplantation. Numerous platelet transfusions, together with sustained thrombocytopenia, inhibited accurate assessment of 29 of 31 patients. Two patients; however, demonstrated a rise in the mean platelet volume prior to an increase in the platelet count. Both of these patients received no platelet transfusions during the period preceding or following the rise in the platelet count. It was proposed that the serial evaluation of the mean platelet volume may assist practitioners in the decision making process of deciding whether platlet transfusions are required, or an increase in the number of circulating platelets is imminent. A decision not to transfuse would have the direct benefit of decreasing patient costs, in conjunction with eliminating a potential source for the development of an antibody against platelets.


Descriptors :   *BONE MARROW , *BLOOD VOLUME , *BLOOD PLATELETS , *LEUKEMIA , *SURGICAL TRANSPLANTATION , SIZES(DIMENSIONS) , THESES , CHEMOTHERAPY , BLOOD COUNTS , BLOOD TRANSFUSION , THROMBOCYTOPENIA , RADIOTHERAPY , REJUVENATION


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE