Accession Number : ADA167600


Title :   Mortality of Munitions Workers Exposed to Dinitrotuluene


Descriptive Note : Final rept. Jul 1980-Jan 1986


Corporate Author : CHEMICAL INDUSTRY INST OF TOXICOLOGY RESEARCH TRIANGLE PARK NC


Personal Author(s) : Levine, Richard J ; Andjelkavich, Dragana A ; Kersteter, Sharon L ; Apr, Jr , Earl W ; Balogh, Sandor A ; Bluneden, Patricia B ; Stanley, John M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a167600.pdf


Report Date : Jan 1986


Pagination or Media Count : 39


Abstract : To determine whether the carcinogenicity of dinitrotoluene (DNT) in rodent bioassays had relevance for humans, we examined the mortality experience of exposed workers at two ammunition plants. Cohorts of 156 and 301 men who had worked a month or more during the 1940s and 1950s at jobs with opportunity for substantial DNT exposure were followed through the end of 1980. Numbers of expected deaths and standardized mortality ratios (SMRs) were computed, using mortality rates of U.S. white males as the standard. No evidence of a carcinogenic effect was found, but unsuspected excesses of mortality from ischemic heart disease were noted at both plants (SMRs 143 an 131: 95% confidence limits 65-234 and 107-187, respectively). Deaths from ischemic heart disease remained high even when compared to expected numbers derived using mortality rates of the counties in which the plants were located. Additional analyses revealed evidence of a 15 year latent period and suggested a relationship with duration and intensity of exposure. Epidemiological investigations of other heavily exposed populations are needed to confirm the etiological significance of the association between DNT and heart disease described here. Keywords: Ammunition; Arteriosclerosis; Neoplasms; and Occupational diseases.


Descriptors :   *CARCINOGENS , *CORONARY DISEASE , *DNT , *ISCHEMIA , *MORTALITY RATE , *OCCUPATIONAL DISEASES , AMMUNITION , ARTERIES , BIOASSAY , CARDIOVASCULAR DISEASES , DISEASES , EPIDEMIOLOGY , EXPOSURE(PHYSIOLOGY) , HEART , HUMANS , INDUSTRIAL PERSONNEL , INDUSTRIAL PLANTS , INTENSITY , MUNITIONS INDUSTRY , NEOPLASMS , POPULATION , RATIOS , RODENTS , STANDARDIZATION


Subject Categories : Medicine and Medical Research
      Toxicology
      Ammunition and Explosives
      Environmental Health and Safety


Distribution Statement : APPROVED FOR PUBLIC RELEASE