Accession Number : ADA159048


Title :   Effects of Acetylcholinesterase Inhibition on Cholinergic Transmission in the Hippocampal Slice.


Descriptive Note : Interim rept. 1 Nov 82-30 Sep 84,


Corporate Author : CALIFORNIA UNIV IRVINE DEPT OF PSYCHOBIOLOGY


Personal Author(s) : Lynch,G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a159048.pdf


Report Date : 08 Feb 1985


Pagination or Media Count : 20


Abstract : This research program is concerned with the long-term consequences of prolonged elevation of acetylcholine on cholinergic and non-cholinergic transmission in hippocampal synapses and the mechanisms through which any such effects might be achieved. Progress has been made in three areas: (1) a cholinergically mediated physiological response has been identified in the in vitro hippocampal slice, (2) the response of the hippocampus to repeated applications of cholinergic agonists has been found to be relatively constant, particularly when compared to that elicited by activation of two types of receptors for adicic amino acids, and (3) the stimulation of a potentially very potent second messenger system (turnover of phosphatidylinositol) by cholinergic agonists was discovered to be completely blocked by concurrent activation receptors for amino acid transmitters. These results point to the conclusions that the cholinergic receptor is not particular labile and that its interaction with its second messenger target system is tightly regulated by noncholinergic inputs.


Descriptors :   *ACETYLCHOLINESTERASE , *CHOLINESTERASE INHIBITORS , *ACETYLCHOLINE , ACTIVATION , STIMULATION(PHYSIOLOGY) , STIMULATION(GENERAL) , IN VITRO ANALYSIS , PHYSIOLOGICAL EFFECTS , RESPONSE(BIOLOGY) , ELEVATION , INHIBITION , SYNAPSE , SENSE ORGANS , AMINO ACIDS , CHOLINERGIC NERVES , HIPPOCAMPUS , NERVE TRANSMISSION , NEUROCHEMICAL TRANSMISSION


Subject Categories : Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE