Accession Number : ADA147616
Title : Clonidine and Cortical Plasticity: Possible Evidence for Noradrenergic Involvement.
Descriptive Note : Technical rept.,
Corporate Author : BROWN UNIV PROVIDENCE RI CENTER FOR NEURAL SCIENCE
Personal Author(s) : Nelson,S B ; Schwartz,M A ; Daniels,J B
Report Date : 31 Oct 1984
Pagination or Media Count : 31
Abstract : In order to test the hypothesis that noradrenergic transmission modulates ocular dominance plasticity in kitten visual cortex, we monocularly deprived kittens while administering the alpha-2 adrenergic agonist clonidine (CLON). To avoid bias in testing hypothesis, we included, with a single blind technique, saline-treated control kittens in the series. First, using high pressure liquid chromatography, we demonstrated that CLON treatments resulted in an average decline in cere-brospinal fluid levels of the norepinephrine metabolite, 3-methoxy-4-hydroxy phenylethlene glyolol of 44%. Then single unit recording in area 17 revealed the expected ocular dominance (OD) shift in monocularly depvied saline controls, but recording failed to find any shift in CLON treated kittens. Our results support the notion that CLON treatment interferes with ocular dominance plasticity by inhibiting noradrenergic transmission in visual cortex. We discuss side effects of CLON, concluding that CLON's sedative effect may contribute to the lack of OD shift.
Descriptors : *VISUAL CORTEX , STIMULATION(PHYSIOLOGY) , HIGH PRESSURE , LIQUID CHROMATOGRAPHY , PHYSIOLOGICAL EFFECTS , NOREPINEPHRINE , EYE , METABOLITES , CATS
Subject Categories : Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE