Accession Number : ADA140236


Title :   Development of Vaccines to Prevent Wound Infections due to Anaerobic Bacteria


Descriptive Note : Annual rept. no. 7, 1 Sep 1979-31 Aug 1980


Corporate Author : PETER BENT BRIGHAM HOSPITAL BOSTON MA


Personal Author(s) : Kasper, Dennis L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a140236.pdf


Report Date : Aug 1980


Pagination or Media Count : 43


Abstract : The amount of capsular antigen produced by Bacteroides fragilis appears to significantly decrease with in vitro passage on blood agar plates of strain 23745. This decrease in the quantity of isolatable capsule is associated with the emergence of a small transparent colony type variant (SCT). The small colony type strain also has a glycogen-like material associated with its outer membrane. This glycogen is found intracellulary, but is not associated with the outer membrane on the mucoid colony variant which predominates after animal passage, the large colony type (LCT). There is no concomitant alteration in outer membrane proteins or lipopolysaccharides associated with this colonial transformation. A series of experiments were designed in the model of intraabdominal sepsis to determine the cellular mechanisms of immunity induced by the capsular antigen to both the bacteremic and abscess phase of this disease. These studies which are presented in the second section of this report conclude that both cellular and humoral limbs of the immune system play important roles in protection against B fragilis infection.


Descriptors :   *VACCINES , WOUNDS AND INJURIES , INFECTIOUS DISEASES , BACTERIAL DISEASES , PREVENTIVE MEDICINE , ANAEROBIC BACTERIA


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE