Accession Number : ADA133974


Title :   Mutagenic Potential of 4-Nitrophenyl Monochloromethyl (Phenyl) Phosphinate Using the Drosophila melanogaster Sex-Linked Recessive Lethal Test.


Descriptive Note : Final rept. 26 Jul-20 Dec 82,


Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA


Personal Author(s) : Powers,Nelson R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a133974.pdf


Report Date : Aug 1983


Pagination or Media Count : 30


Abstract : 4-Nitrophenyl monochloromethyl (phenyl) phosphinate (TA009) is being considered as a prophylactic agent in anticholinesterase poisoning. It was tested for mutagenic activity using Drosophila melanogaster sex-linked recessive lethal assay. After 72-hour feeding exposures to 0.0100, 0.500, and 0.0075 mM, TA009 appeared non-mutagenic.


Descriptors :   *Phosphinates , *Toxicology , *Mutagens , Phenyl radicals , Nitro radicals , Methyl radicals , Chlorine compounds , Bioassay , Drosophila , Genetics , Damage


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE