Accession Number : ADA131310


Title :   Immunologic Control of Diarrheal Disease Due to Enterotoxigenic Escherichia coli: Reactogenicity, Immunogenicity, and Efficacy Studies of Pili Vaccines


Descriptive Note : Annual rept. 1 Feb-31 Dec 1981


Corporate Author : MARYLAND UNIV BALTIMORE DIV OF INFECTIOUS DISEASES


Personal Author(s) : Levine, Myron M ; Black, Robert E ; Clements, Mary Lou ; Kaper, James B


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a131310.pdf


Report Date : Sep 1981


Pagination or Media Count : 67


Abstract : Purified type 1 somatic pill from enterotoxigenic Escherichia coli (ETEC) strain H10407 (078:H11) was evaluated as a parenteral immunizing pilus vaccine. Intramuscular inoculation with 45, 90, 900 or 1800 mcg of pili vaccine was tolerated without incident in 82 volunteers. Six of 15 persons who received a 28 day booster of 1800 mcg developed local reactions while none of 52 persons receiving 180 or 450 mcg boosters evinced such reactions. Pili vaccine did not significantly alter intestinal transit time, absorptive capacity or the prevalence of colonic E. coli bearing type 1 somatic pili of the H10407 antigenic variety. Parenterally inoculated type 1 somatic pili were safe and highly immunogenic in man but did not consistently include protection.


Descriptors :   *DIARRHEA , *IMMUNOLOGY , *VACCINES , EXPERIMENTAL DATA , HUMANS , ADHESION , ESCHERICHIA COLI , ENTEROTOXINS , STRAINS(BIOLOGY) , DOSAGE , ANTIBODIES , IMMUNITY , ANTIGENS , IMMUNIZATION , PATHOGENIC MICROORGANISMS , BACTERIAL TOXINS , LABORATORY ANIMALS , HAIR


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE