Accession Number : ADA131049

Title :   Stability of Rat Brain Glutamine Synthetase to Oxygen Toxicity (Oxygen at High Pressure).

Descriptive Note : Final rept.,

Corporate Author : AIR FORCE ACADEMY CO

Personal Author(s) : Webb,James T

Full Text :

Report Date : Jul 1983

Pagination or Media Count : 17

Abstract : Enzyme assays using the gamma-glutamyl transferase method provided estimates of glutamine synthetase activity in rat brain homogenates subjected to a pure oxygen environment for over three hours. No loss of activity was detected versus controls subjected to air or pure nitrogen. This finding supports the lack of any connection between convulsions caused by in vivo inhibition of glutamine synthetase and convulsions caused by oxygen toxicity (oxygen at high pressure). (Author)

Descriptors :   *Toxicity , *Oxygen , *Enzymes , *Glutamine , *Brain , *Rats , High pressure , Bioassay , Transferases , Convulsive disorders , Inhibition , In vivo analysis , Chemical radicals , Oxidation , Carboxy lyases , Butyric acids , Partial pressure , Hyperbaric conditions

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE