Accession Number : ADA130593


Title :   Immunological Interrelationships of Coliform Heat-Labile and Heat-Stable Enterotoxins


Descriptive Note : Annual progress rept. no. 13, 15 Jan 1980-15 Jan 1981


Corporate Author : ROCHESTER UNIV NY SCHOOL OF MEDICINE AND DENTISTRY


Personal Author(s) : Klipstein, Frederick A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a130593.pdf


Report Date : Jan 1981


Pagination or Media Count : 13


Abstract : The goal of these studies is the development of an immunization program to prevent acute diarrheal disease due to intestinal contamination of enterotoxigeneic strains of Escherichia coli. We have demonstrated (a) that the holotoxin is the most immunogenic form of the E. coli heat-labile enterotoxin, (b) that immunization with this material protects rats against challenge with heterologous serotypes of E. coli, and (c) that the degree of protection is influenced by the route, schedule and dosage of both the primary and booster immunizations.


Descriptors :   *DIARRHEA , *ENTEROTOXINS , *IMMUNIZATION , RATS , ESCHERICHIA COLI , STRAINS(BIOLOGY) , DOSAGE , IMMUNE SERUMS , HEAT , IMMUNOASSAY , CHOLERA , IMMUNOGENS , COLIFORM BACTERIA , GERM FREE ANIMALS


Subject Categories : Medicine and Medical Research
      Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE