Accession Number : ADA130592


Title :   Immunologic Interrelationships of Coliform Heat-Labile and Heat-Stable Enterotoxins


Descriptive Note : Annual progress rept. no. 10, 15 Jan 1979-15 Jan 1980


Corporate Author : ROCHESTER UNIV NY SCHOOL OF MEDICINE AND DENTISTRY


Personal Author(s) : Klipstein, Frederick A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a130592.pdf


Report Date : 15 Jan 1980


Pagination or Media Count : 14


Abstract : The goal of these studies is the development of an immunization program to prevent diarrheal disease due to intestinal contamination by enterotoxigenic strains of coliform bacteria. We have found that immunization with the polymyxin-release form of Escherichia coli heat-labile enterotoxin by means of a parenteral prime followed by peroral boosts yields the combination of maximum immediate and extended protection and demonstrated that this immunization regimen is totally protective when gnotobiotic rats are challenged by intestinal contamination with strains of E. coli which produce the heat-labile toxin.


Descriptors :   *DIARRHEA , *ENTEROTOXINS , *IMMUNIZATION , RATS , TEST METHODS , ESCHERICHIA COLI , STRAINS(BIOLOGY) , DOSAGE , IMMUNE SERUMS , HEAT , PREVENTIVE MEDICINE , IMMUNOGENS , COLIFORM BACTERIA , GERM FREE ANIMALS , KLEBSIELLA PNEUMONIAE


Subject Categories : Medicine and Medical Research
      Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE