Accession Number : ADA121284


Title :   Chemical Carcinogen (Hydrazine et al.) Induced Carcinogenesis of Human Diploid Cells in Vitro


Descriptive Note : Annual progress rept. 1 Sep 1981-31 Aug 1982


Corporate Author : OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS


Personal Author(s) : Milo, G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a121284.pdf


Report Date : 07 Sep 1982


Pagination or Media Count : 102


Abstract : Polynuclear hydrocarbons or hydrazine analogues do not have an absolute requirement for binding to DNA in order to elicit a carcinogenic event. Furthermore, PNH like BP enter the nucleus via a lipoprotein complex where the BP is oxygenated and then interacts with the genetic material,(DNA). The adduct formed is 7 beta-BPEDI-dG. Benzamide does not alter the binding of the perceived ultimate carcinogen to dG but eliminates the carcinogenic response. The period of heightened response to the carcinogen appears to be 3 hours into S phase of the cell type. The modifying effect of TPA or Benzamide appears to alter the nuclear non-histone proteins protecting the cellular DNA.


Descriptors :   *HYDRAZINES , *TOXICITY , *CARCINOGENS , *ONCOGENESIS , HUMANS , METABOLISM , DEOXYRIBONUCLEIC ACIDS , IN VITRO ANALYSIS , TRANSPORT PROPERTIES , FIBROBLASTS , MICE , CHICKENS , CELLS(BIOLOGY) , SKIN(ANATOMY) , TRANSFORMATIONS


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE