Accession Number : ADA118818


Title :   Artificial Red Cells with Polyhemoglobin Membranes.


Descriptive Note : Final rept. 1 Oct 80-30 Jun 81,


Corporate Author : EXXON RESEARCH AND ENGINEERING CO LINDEN N J


Personal Author(s) : Davis,Thomas A ; Asher,William J ; Quinlan,George T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a118818.pdf


Report Date : Sep 1981


Pagination or Media Count : 43


Abstract : Artificial red cells were prepared with polyhemoglobin membranes. Red-cell-size microdroplets containing 30% of hemoglobin were held in liquid membrane capsules and treated with glutaraldehyde that cross linked the hemoglobin at the surface of each microdroplet. A water-soluble surfactant was used to eject the cells from the oil and suspend them in saline. The hemoglobin was retained by the artificial red-cell membrane, but biotonometry revealed that it held oxygen more tenaceously after encapsulation. (Author)


Descriptors :   *Blood substitutes , *Hemoglobin , Encapsulation , Erythrocytes , Membranes(Biology) , Polymers


Subject Categories : Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE