Accession Number : ADA103149


Title :   Study of Shigella Vaccines in Man.


Descriptive Note : Annual rept. 16 Aug 73-15 Aug 74,


Corporate Author : MARYLAND UNIV BALTIMORE DIV OF INFECTIOUS DISEASES


Personal Author(s) : Hornick,Richard B


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a103149.pdf


Report Date : 15 Aug 1974


Pagination or Media Count : 15


Abstract : Studies have continued to evaluate the safety, biologic properties and efficacy of various oral Shigella vaccine candidates. The most recent vaccine candidates employed have been Escherichia coli bearing Shigella group antigens. These vaccine candidates are noteworthy in that they are completely safe with no potential for reversion and they appear to proliferate within the human bowel. In several protocols, however, involving concomitant challenge of both vaccinated and non-vaccinated volunteers with varied doses of virulent S. flexneri 2a, attack rates were similar and a protective effect of the vaccine strain could not be demonstrated.


Descriptors :   *VACCINES , *SHIGELLA , *DYSENTERY , HUMANS , ESCHERICHIA COLI , STRAINS(BIOLOGY) , IMMUNITY , IN VIVO ANALYSIS , VIRULENCE , ANTIGENS , ORAL DOSAGE , LACTOSE , INFECTIOUS DISEASE TRANSMISSION , EXCRETION , CHEMICAL DERIVATIVES , SHIGELLA DYSENTERIAE , SHIGELLA FLEXNERI


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE