Accession Number : ADA100072


Title :   In Vitro Response of Guinea Pig Peritoneal Macrophages to Legionella pneumophila


Descriptive Note : Journal article


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Kishimoto, R A ; White, J D ; Shirey, F G ; McGann, V G ; Berendt, R F


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a100072.pdf


Report Date : Mar 1981


Pagination or Media Count : 5


Abstract : Transmission and scanning electron microscopy were used to study the phagocytosis of virulent and avirulent strains of Legionella pneumophila. The interaction between L. pneumophila and peritoneal macrophages from normal guinea pigs or from animals that had survived infection was studied. The virulent strains survived and proliferated within the phagocyte after ingestion by either type of macrophage, whereas the avirulent strain of bacteria was killed by normal macrophages. Although the addition of immune serum enhanced phagocytosis, the outcome was the same as with normal serum.


Descriptors :   *LEGIONELLA PNEUMOPHILA , BACTERIOPHAGES , ELECTRON MICROSCOPY , GUINEA PIGS , IN VITRO ANALYSIS , PHAGOCYTES , REPRINTS , RESPONSE(BIOLOGY)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE