Accession Number : ADA098650


Title :   The Role of Electronically Excited States and Free Radicals in Ultraviolet-Induced Lens Opacification.


Descriptive Note : Final rept. 15 Mar 78-15 Mar 79,


Corporate Author : DUKE UNIV DURHAM NC DEPT OF ELECTRICAL ENGINEERING


Personal Author(s) : Hacker,Herbert ; Yamanashi,Bill S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a098650.pdf


Report Date : Dec 1980


Pagination or Media Count : 86


Abstract : Ocular lens safety criteria with respect to UV radiation wavelength and dosage are outlined. These criteria are based on spectroscopic and biochemical studies of UV-exposed and control lenses as well as isolated lens proteins. Excited states of tryptophan in the lens crystallin proteins are implicated as the major species responsible for UV-induced cataractogenesis; possible causal mechanisms including crosslinking of peptides are suggested. (Author)


Descriptors :   *ULTRAVIOLET RADIATION , *OPACITY , *CATARACTS , *LENS(EYE) , PEPTIDES , EXCITATION , PROTEINS , CROSSLINKING(CHEMISTRY) , FREE RADICALS , RADIATION DOSAGE , RADIATION EFFECTS , TRYPTOPHAN , RADIOBIOLOGY , RADIATION CHEMISTRY


Subject Categories : Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE