Accession Number : ADA096592


Title :   Survival of Primates in Lethal Septic Shock Following Delayed Treatment with Steroid.


Descriptive Note : Technical rept.,


Corporate Author : OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY


Personal Author(s) : Hinshaw,L B ; Archer,L T ; Beller-Todd,B K ; Benjamin,B ; Flournoy,D J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a096592.pdf


Report Date : 26 Feb 1981


Pagination or Media Count : 29


Abstract : We recently developed a methylprednisolone sodium succinate (MPSS)/gentamicin sulfate (GS) regimen that prevented death in baboons given a 2-hour infusion of LD100 E. coli (J. Surg. Res. 28:151, 1980). Steroid treatment was begun in that study 30 minutes after initiation of E. coli. Our current aim was to determine if baboons would survive if MPSS treatment was delayed until all E. coli were infused and severe hypotension had ensued. Fourteen lightly anesthetized baboons (Papio c. cynocephalus) were administered E. coli and seven were then treated with MPSS and GS for 10 hours. All nontreated baboons died while 6 of 7 treated animals survived. In the treated group, hypoglycemia and hypoinsulinemia were reversed, tachycardia was reduced and neutrophil recovery was improved. Baboons with delayed MPSS, however, evidenced diminished perfusion and recovered slower than those with earlier MPSS treatment. In conclusion, primates in septic shock are clearly protected with delayed steroid/antibiotic therapy. (Author)


Descriptors :   *ESCHERICHIA COLI , *ANTIBIOTICS , *STEROIDS , *ENDOTOXIC SHOCK , RECOVERY , RATES , SURVIVAL(GENERAL) , PRIMATES , BACTERIAL TOXINS , SHOCK(PATHOLOGY) , CHEMOTHERAPY , BABOONS


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE