Accession Number : ADA096475


Title :   Synthetic Analogs of Phospholipid Metabolites as Antimalarials.


Descriptive Note : Final rept. 1 Jul 76-30 Sep 78,


Corporate Author : LONG ISLAND JEWISH-HILLSIDE MEDICAL CENTER NEW HYDE PARK NY


Personal Author(s) : Rosenthal,Arthur F


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a096475.pdf


Report Date : Jul 1979


Pagination or Media Count : 196


Abstract : Analogs of phospholipids and their biosynthetic intermediates were synthetic targets as novel potential antimalarials. Targeted analogs contained one or more types of non-hydrolyzable groups, including ether, phosphonate, and phosphinate moieties. Synthetic routes varied with each target, and were quite complex for the cytidine-containing analogs of the biosynthetic intermediates, involving a number of novel steps. The phospholipid analogs were successfully prepared and submitted. However, during the course of the contract syntheses of the major cytidine-containing target compounds could not be completed, although a monophosphonate 'model analog' was prepared and submitted. None of the thirteen compounds (including three targets and one 'model target') submitted displayed appreciable antimalarial activity in vivo in the standard test system. (Author)


Descriptors :   *ANTIMALARIALS , ETHERS , PHOSPHONATES , BIOSYNTHESIS , METABOLITES , PHOSPHOLIPIDS , CHEMICAL ANALOGS , PHOSPHINATES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE