Accession Number : ADA094643


Title :   The Action of Botulinum Toxin at the Neuromuscular Junction


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Sellin, Lawrence C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a094643.pdf


Report Date : 22 Dec 1980


Pagination or Media Count : 36


Abstract : Botulism results from the action is of a protein neurotoxin (MW approx. 150,000) produced by the bacterium Clostridium botulinum, of which there are eight known strains. Botulinum neurotoxin is the most potent biological toxin known, having a median lethal dose of 5-50 ng/kg body weight. The primary site of action of botulinum toxin is the cholinergic nerve terminal, where it blocks the release of the neurotransmitter acetylcholine. Death usually results from respiratory failure. Nonlethal doses of botulinum toxin can induce sprouting of the nerve terminal and have significant postsynaptic effects, including muscle atrophy and alterations in the membrane electrical properties of the muscle fiber. There is no universally available treatment for botulinum intoxication. However, immunotherapeutic and chemotherapeutic procedures are now being developed and will be discussed.


Descriptors :   *BACTERIAL TOXINS , *CLOSTRIDIUM BOTULINUM , LITERATURE SURVEYS , PHYSIOLOGICAL EFFECTS , DOSAGE , RELEASE , ACETYLCHOLINE , NEUROMUSCULAR TRANSMISSION , INTOXICATION , CHOLINERGIC NERVES , THERAPY , MUSCLES , JUNCTIONS , NERVES


Subject Categories : Medicine and Medical Research
      Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE