Accession Number : ADA094639


Title :   Hepatic Concentration and Distribution of Coenzyme A and Carnitine during a Streptococcus pneumoniae Infection in the Rat: Possible Implications on Fatty Acid Metabolism and Ketogenesis


Descriptive Note : Interim rept.,


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Pace, Judith G ; Beall, Francis A ; Neufeld, Harold A ; Wannemacher, Jr, Robert W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a094639.pdf


Report Date : 09 Jan 1981


Pagination or Media Count : 39


Abstract : Rats infected with Streptococcus pneumoniae were used to study the effect of pneumococcal infection on the hepatic concentrations and the subcellular distribution of carnitine and coenzyme A (CoA). Compared to fasted control rats, fasted-infected rats have a decreased ketogenic capacity that is associated with an accumulation of total hepatic carnitine and a decrease in total hepatic coenzyme A. The concentration of competing substrates (e.g., lactate and pyruvate) and nucleotide ratios (e.g., (Acetyl-CoA)/(CoA), (ATP)/ (ADP)(HPO4(2-)), and (NAD+)/(NADH)) are also variably affected by the infection. The concentrations of both lactate and pyruvate and the mitochondrial ratio of (NAD+)/(NADH) increased, while mitochondrial (acetyl-CoA)/(CoA) and the phosphorylation state or the (ATP)/(ADP)(HPO4(2-) ratio decreased compared to fasted controls.


Descriptors :   *FATTY ACIDS , *STREPTOCOCCAL PNEUMONIA , RATS , METABOLISM , LIVER , COENZYMES , INFECTIOUS DISEASES , BACTERIAL DISEASES


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE