Accession Number : ADA090912


Title :   Modification of Lethality Induced by Staphylococcal Enterotoxin B in Dutch Rabbits


Descriptive Note : Journal article


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Liu, C T ; Sanders, R P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a090912.pdf


Report Date : Mar 1980


Pagination or Media Count : 6


Abstract : Intramuscular injection of staphylococcal enterotoxin B (SEB) at a dosage level of 50 micrograms/kg of body weight caused death in Dutch rabbits. Lethality was not modified markedly by morphine pretreatment or by hyperthermia, thyrotoxicosis, propylthiouracil feeding, thyroparathydroidectomy, water deprivation, or fasting. The administration of acetylsalicylic acid to the SEB-inoculated rabbit also failed to protect the rabbits from the effect of SEB. Seemingly, the SEB molecular destruction was not markedly modified by alteration of cellular metabolism, and lethal effects of SEB remained unchanged in the morphine- or acetylsalicylic acid-treated rabbits. When SEB was given to six rabbits 3 days after total-body X-irradiation, fewer persisted and three rabbits survived. An identical dose of SEB to nonirradiated rabbits produced fever initially, followed by hypothermia and death of all rabbits.


Descriptors :   *BACTERIAL TOXINS , *ENTEROTOXINS , *STAPHYLOCOCCUS , LETHAL DOSAGE , LETHALITY , MORPHINE , RABBITS , REPRINTS , SALICYLIC ACIDS , WHOLE BODY IRRADIATION , X RAYS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE