Accession Number : ADA083561


Title :   Ribavirin Treatment of Toga-, Arena- and Bunyavirus Infections in Subhuman Primates and Other Laboratory Animal Species


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Stephen, Edward L ; Jones, Dennis E ; Peters, Clarence J ; Eddy, Gerald A ; Loizeaux, Peter S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a083561.pdf


Report Date : Sep 1979


Pagination or Media Count : 18


Abstract : Ribavirin was effective in reducing viremia and increasing the number of survivors compared to untreated monkeys infected with Rift Valley fever (a bunyavirus), Lassa or Machupo (both arenaviruses) viruses. Treatment was effective when given initially at the time of virus inoculation or later, after the onset of viremia and fever. Only minimal effect was evident against yellow fever virus (a flavivirus) infection in rhesus monkeys, even when treatment was initiated within 8 hours after virus inoculation. Ribavirin was ineffective against Chikungunya virus (an alphavirus) infection of monkeys. The apparent inability of ribavirin to achieve effective concentrations in the central nervous system may limit its usefulness against viruses causing primary encephalitis.


Descriptors :   *ANTIVIRAL AGENTS , MICE , RIFT VALLEY FEVER , CENTRAL NERVOUS SYSTEM , CHEMOTHERAPY , RHESUS MONKEYS , MONKEYS , CHIKUNGUNYA VIRUS , YELLOW FEVER VIRUS


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE