Accession Number : ADA065776


Title :   Immunologic Interrelationships of Coliform Heat-Labile and Heat-Stable Enterotoxins


Descriptive Note : Rept. no. 7 (Annual) 15 Feb 1978-15 Jan 1979


Corporate Author : ROCHESTER UNIV NY SCHOOL OF MEDICINE AND DENTISTRY


Personal Author(s) : Klipstein, Frederick A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a065776.pdf


Report Date : 15 Jan 1979


Pagination or Media Count : 12


Abstract : The goal of these studies is the development of an immunization program to prevent diarrheal disease due to intestinal contamination by enterotoxigenic strains of coliform bacteria. We have demonstrated that (a) active immunization with a purified preparation of the polymyxin release form of Escherichia coli heat-labile enterotoxin yields protection against strains of this bacteria which produce this form of toxin; (b) the use of cimetidine renders the peroral route of immunization effective; and (c) peroral, but not parenteral, immunization affords extended protection.


Descriptors :   *DIARRHEA , *IMMUNIZATION , ESCHERICHIA COLI , COLIFORM BACTERIA , GERM FREE ANIMALS , PREVENTIVE MEDICINE , ENTEROTOXINS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE