Accession Number : ADA058568


Title :   Investigation of 'Escherichia coli' Enterotoxins


Descriptive Note : Final rept. 1 Aug 1973-30 Sep 1977


Corporate Author : WYETH LABS INC PHILADELPHIA PA


Personal Author(s) : Rappaport, Ruth


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a058568.pdf


Report Date : May 1978


Pagination or Media Count : 16


Abstract : The results of the present investigation indicate a new approach to the development of a single vaccine formula which may ultimately be used to confer protection against both cholera and E. coli diarrheal disease in man and domestic animals. Fundamentally, the design of the vaccine is based on the well- documented ability of cholera antitoxin to neutralize both cholera and heat- labile E. coli enterotoxins and on the ability of certain E. coli antigens to enhance the immune response to cholera toxoid and possibly whole-cell Cholera Vaccine, as well.


Descriptors :   *ESCHERICHIA COLI , *DIARRHEA , PURIFICATION , STRAINS(BIOLOGY) , PROTECTION , IMMUNOLOGY , ANTIGENS , PATHOGENESIS , TRYPSIN , CHOLERA , VACCINES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE