Accession Number : ADA057073


Title :   Effect of EEG Biofeedback on Convulsive Response to Monomethylhydrazine in the Rhesus Monkey


Descriptive Note : Annual rept. 1 Aug 1976-31 Jul 1977


Corporate Author : CALIFORNIA UNIV LOS ANGELES SCHOOL OF MEDICINE


Personal Author(s) : Sterman, M B ; Goodman, S J ; Fairchild, M D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a057073.pdf


Report Date : Jun 1978


Pagination or Media Count : 18


Abstract : Toxic and convulsive responses to monomethylhydrazine (MMH) were compared in two groups of rhesus monkeys. One group received 12 weeks of feedback training with reinforcement provided for the production of rhythmic central cortical 12-14 Hz EEG activity (the sensorimotor rhythm or SMR) in the absence of movement and concurrent 8-11 Hz EEG activity. A second group was studied also but without feedback training. Three of the four trained animals demonstrated reliable acquisition of the rewarded response. Following training a convulsive dose of MMH was administered to both groups. Trained animals showed a significantly prolonged latency to generalized seizures, fewer overall seizures, and a greater incidence of sustained quiescent behavior. Toxic responses, including emesis and episodes of agitated behavior, were comparable among the two groups. These findings indicate that threshold for MMH induced seizures can be modified in primates through EEG feedback training, as shown previously in the cat. A specific change in central motor control mechanisms is proposed as an explanation for this effect.


Descriptors :   *HYDRAZINES , *CONVULSIVE DISORDERS , *TOXIC TOLERANCES , TRAINING , CENTRAL NERVOUS SYSTEM , BIOFEEDBACK , SENSE ORGANS , RHESUS MONKEYS , ELECTROENCEPHALOGRAPHY , MOTOR NEURONS


Subject Categories : Anatomy and Physiology
      Toxicology
      Organic Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE