Accession Number : ADA010062


Title :   Serum Zinc, Iron, and Copper Concentrations during Typhoid Fever in Man: Effect of Chloramphenicol Therapy


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Pekarek, Robert S ; Kluge, R M ; DuPont, H L ; Wannemacher, Jr , R W ; Hornick, R B


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a010062.pdf


Report Date : 12 Nov 1974


Pagination or Media Count : 6


Abstract : In volunteers experimentally infected with Salmonellatyphi, serum iron and zinc concentrations became significantly depressed and there was a concomitant rise in serum copper before the onset of overt clinical illness. However, after several days of fever and the initiation of chloramphenicol therapy, serum iron and zinc concentrations significantly increased. Additional studies-in volunteers with typhoid fever treated with chloramphenicol, in a volunteer with typhoid fever receiving cefazolin and gentamicin, and in untreated rhesus monkeys infected with Salmonella typhimurium-provided evidence that the increase in serum iron concentration during the febrile phase was the result of chloramphenicol therapy, whereas the increase in serum zinc concentrations was a disease-related phenomenon. The importance of trace-metal monitoring during infectious disease and chemotherapy is discussed.


Descriptors :   *FEVERS , *CHLORAMPHENICOL , *SALMONELLA TYPHOSA , *TYPHOID , REPRINTS , IRON , COPPER , CONCENTRATION(COMPOSITION) , TRACE ELEMENTS , ZINC , THERAPY , INFECTIOUS DISEASES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE