Accession Number : AD1051161


Title :   Further Development of an Exhaled microRNA Biomarker of Lung Cancer Risk


Descriptive Note : Technical Report,15 Jul 2016,14 Jul 2017


Corporate Author : Albert Einstein College of Medicine, Inc. Bronx United States


Personal Author(s) : Spivack,Simon D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1051161.pdf


Report Date : 01 Aug 2017


Pagination or Media Count : 153


Abstract : We seek to devise a non-invasive airway based exhaled microRNA metric for lung cancer risk, initial work to be tested in a case control study. We expanded the microRNA panel to 30microRNAs, and expanded the cohort beyond Einstein-Montefiore/Bronx to include Bronx /J Peters VAH clinic-based recruits, in a case-control study. We also expanded the assessment of lung cancer subjects to also include limited (3-month) prospective follow-up of non-cancer controls in order to minimize control contamination/misclassification, and improved matching on age, smoking status, and underlying COPD (initial n90 versus n90 controls). In essence we were able to detect a discriminant signature from exhaled microRNAs, whereby discriminant accuracy over and above clinical criteria alone, was improved by 3-8.


Descriptors :   lung cancer , biological detection , rna , biological markers , molecular biology , neoplasms , stem cells , patient care , surgery , therapy , genetics


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE