Accession Number : AD1051075


Title :   Blast Induced Thresholds for Neuronal Networks (BITNeT)


Descriptive Note : Technical Report,01 Oct 2010,31 Dec 2016


Corporate Author : University of Pennsylvania Philadelphia United States


Personal Author(s) : Bass,Dale ; Morrison,Barclay ; Meaney,David F ; Abel,Ted


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1051075.pdf


Report Date : 19 Jun 2017


Pagination or Media Count : 262


Abstract : Connecting the human brain response to blast loading across multiple length scales from synapses through to circuit pathways and neurobehavior remains a key challenge for developing countermeasures to limit the effects of blast in the military. Our MURI intends to help fill this gap by conducting a series of experiments connecting cell, tissue, and animal responses, developing scaling rules to predict the human experience. We examine circuits constructed in vitro and in vivo, and assess the effect of blast-induced circuit changes on the subsequent neurological impairment. We recruited and collaborate with experts in each of the necessary knowledge domains to solve the complex problem of neuronal activation, injury, and tolerance to primary blast injury.


Descriptors :   brain injuries , wave propagation , blast , neurosciences , blood , craniocerebral trauma , cell membrane , NEUROBEHAVIORAL MANIFESTATIONS , military personnel , cells(biology) , tissues , in vitro analysis , in vivo analysisBLAST INJURIES


Subject Categories : Weapons Effects(biological)
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE