Accession Number : AD1051075

Title :   Blast Induced Thresholds for Neuronal Networks (BITNeT)

Descriptive Note : Technical Report,01 Oct 2010,31 Dec 2016

Corporate Author : University of Pennsylvania Philadelphia United States

Personal Author(s) : Bass,Dale ; Morrison,Barclay ; Meaney,David F ; Abel,Ted

Full Text :

Report Date : 19 Jun 2017

Pagination or Media Count : 262

Abstract : Connecting the human brain response to blast loading across multiple length scales from synapses through to circuit pathways and neurobehavior remains a key challenge for developing countermeasures to limit the effects of blast in the military. Our MURI intends to help fill this gap by conducting a series of experiments connecting cell, tissue, and animal responses, developing scaling rules to predict the human experience. We examine circuits constructed in vitro and in vivo, and assess the effect of blast-induced circuit changes on the subsequent neurological impairment. We recruited and collaborate with experts in each of the necessary knowledge domains to solve the complex problem of neuronal activation, injury, and tolerance to primary blast injury.

Descriptors :   brain injuries , wave propagation , blast , neurosciences , blood , craniocerebral trauma , cell membrane , NEUROBEHAVIORAL MANIFESTATIONS , military personnel , cells(biology) , tissues , in vitro analysis , in vivo analysisBLAST INJURIES

Subject Categories : Weapons Effects(biological)
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE