Accession Number : AD1050811


Title :   A Novel Animal Model for Investigating the Neural Basis of Focal Dystonia


Descriptive Note : Technical Report,31 Aug 2016,30 Aug 2017


Corporate Author : The Research Foundation State University of New York Stony Brook United States


Personal Author(s) : Evinger, Leslie


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050811.pdf


Report Date : 01 Sep 2017


Pagination or Media Count : 10


Abstract : The overall goal of the project was to develop an animal model of the focal dystonia benign essential blepharospasm. Consistent with the widely held view that dystonia results from an interaction between a predisposing condition and an environmental trigger, we proposed to use 7 Hz deep brain stimulation of the basal ganglia as the predisposing condition and dry eye as an environmental trigger to model blepharospasm in rodents. This reporting year we demonstrated that 7 Hz is a critical frequency for basal ganglia activity to create the predisposing condition for the development of blepharospasm. In addition, we showed that basal ganglia modulation of the superior colliculus can produce the exaggerated trigeminal excitability typical of blepharospasm.


Descriptors :   eye , cerebellum , ganglia , electric stimulation therapy , neurons


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE