Accession Number : AD1050793

Title :   Noninvasive Detection of AR-FL/AR-V7 as a Predictive Biomarker for Therapeutic Resistance in Men with Metastatic Castration-Resistant Prostate Cancer

Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author : Johns Hopkins University Baltimore United States

Personal Author(s) : Luo, Jun

Full Text :

Report Date : 01 Oct 2017

Pagination or Media Count : 61

Abstract : Understanding primary and acquired resistance to abiraterone and enzalutamide, and developing analytically validated and clinically qualified predictive biomarkers, remains a critically important unmet medical need. We propose non-invasive detection of full-length androgen receptor (AR-FL) and the androgen receptor splice variant 7(AR-V7) (AR-FL/AR-V7) as a predictive biomarker for therapeutic resistance in men with metastatic castration resistant prostate cancer.

Descriptors :   prostate cancer , biological markers , Metastasis , drug resistance , androgens , biopsy , blood chemistry

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE