Accession Number : AD1050793


Title :   Noninvasive Detection of AR-FL/AR-V7 as a Predictive Biomarker for Therapeutic Resistance in Men with Metastatic Castration-Resistant Prostate Cancer


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Johns Hopkins University Baltimore United States


Personal Author(s) : Luo, Jun


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050793.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 61


Abstract : Understanding primary and acquired resistance to abiraterone and enzalutamide, and developing analytically validated and clinically qualified predictive biomarkers, remains a critically important unmet medical need. We propose non-invasive detection of full-length androgen receptor (AR-FL) and the androgen receptor splice variant 7(AR-V7) (AR-FL/AR-V7) as a predictive biomarker for therapeutic resistance in men with metastatic castration resistant prostate cancer.


Descriptors :   prostate cancer , biological markers , Metastasis , drug resistance , androgens , biopsy , blood chemistry


Subject Categories : Medicine and Medical Research
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE