Accession Number : AD1050513


Title :   Severe Alcoholic Pancreatitis-Associated Acute Lung Injury in Veterans: Risks, Mechanisms, Prediction, and Therapeutic Relevance


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Carl T Hayden Medical Research Foundation Pheonix United States


Personal Author(s) : Vela, Stacie A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050513.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 9


Abstract : Background: Acute pancreatitis is a painful, potentially life-threatening condition of the pancreas with an unpredictable course. In this study we hope to identify and propose simple and reliable ways to predict and treat acute pancreatitis. Hypothesis: Alcohol increases systemic bioavailability of unsaturated fatty acids(UFAs). This, along with the resulting hypocalcemia and hypoalbuminemia worsen cell injury. We propose to test a novel yet simple ratio as a reliable predictor and therapeutic target in the management of alcoholic AP. Objective: To compare the [Serum free fatty acid/ (Serum calcium x albumin)] ratio as a predictor of severe alcoholic pancreatitis in veterans vs. other classical and proposed predictors. Methods: Patients admitted with acute pancreatitis are enrolled and laboratory results are recorded. Total of 7 patients and controls have been enrolled to date. Serum samples are obtained and sent to Mayo Clinic, Site 1, for analysis of FFA and circulating dead inflammatory cells. Echocardiogram is done within 24 hours of admission. Control groups include patients who abuse alcohol but do not have pancreatitis and healthy patients. We plan to study the strength of associations of various risk factors for severe acute pancreatitis in comparison to the [Serum free fatty acid/ (Serum calcium x albumin)] ratio. Conclusion: If our hypothesis is true, it would change the paradigm of managing serum calcium and albumin in acute pancreatitis. This would provide a better, novel yet simple predictor and approach to treatment for severe alcoholic pancreatitis, and potentially acute pancreatitis in general.


Descriptors :   PANCREATITIS , therapy , risk factors , hospitals , cardiology , fatty acids , cells (biology) , predictions , alcohols , inflammation , metabolic diseases


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE