Accession Number : AD1050398


Title :   Early Critical Care Decisions and Outcomes after SCI: Track-SCI


Descriptive Note : Technical Report


Corporate Author : University of California, San Francisco San Francisco United States


Personal Author(s) : Beattie, Michael S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050398.pdf


Report Date : 01 Sep 2017


Pagination or Media Count : 40


Abstract : Although there are established standards of care for acute SCI, these vary across trauma centers, and there are in fact very fewevidence-based studies of SCI critical care to provide solid guidance for the many treatment decisions facing the SCI careteam. In short, even the best teams do not know what the best practices are. We are in critical need of more information aboutthe physiology of acute SCI, the variety of critical care treatments and strategies employed by different practitioners, and howthese variables may relate to long-term functional outcomes and QoL, especially with respect to bladder and autonomicfunctions and their relationship to infection. Our objective is to provide a comprehensive prospective analysis of multiplevariables in acute SCI impacting long-term outcomes. The three core hypotheses are 1. Multiple critical care variables will bepredictive of both sensory-motor and autonomic outcomes, and infection susceptibility at 6 and 12 mos after SCI. 2. QuantitativeMRI of cord damage, and biomarkers of acute immune responses to injury will predict neurological outcomes at dischargeand at 6 and 12 mos. 3. Advanced analytics will yield novel predictors of outcome that will facilitate subsequent clinical trials.


Descriptors :   clinical trials , computational science , data science , information processing , data analysis , factor analysis , knowledge management , wounds and injuries , statistical analysis , surgery , brain injuries , information science , databases , spinal cord , spinal injuries , therapy , patient care , spine , medical personnel , health services


Distribution Statement : APPROVED FOR PUBLIC RELEASE