Accession Number : AD1050358


Title :   Regressing Atherosclerosis by Resolving Plaque Inflammation


Descriptive Note : Technical Report,01 Jul 2016,30 Jun 2017


Corporate Author : NEW YORK UNIV NY NEW YORK United States


Personal Author(s) : Loke, Png


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050358.pdf


Report Date : 01 Jul 2017


Pagination or Media Count : 59


Abstract : Macrophages play key roles in progression of atherosclerosis. Our goal is to understand the mechanisms by which atherosclerosis can be clinically regressed by altering the macrophage state in the plaques to resolve the inflammation, as well as to develop new therapeutic strategies to promote atherosclerosis regression by altering the macrophage activation state. We have found that successful atherosclerosis regression requires the alteration of macrophages in the plaques to a tissue repair alternatively activated state. This switch in activation state requires the action of TH2 cytokines interleukin (IL)-4 or IL-13. To accomplish our goals, we are testing if these molecules, or derivative of these molecules, will be able to accelerate atherosclerosis regression in mouse models. Additionally, we will develop nanomedicines that can favorably and rapidly affect the content and inflammatory state of macrophages in atherosclerotic plaques to promote regression. Concurrently, we will characterize the macrophages to understand the mechanisms that promote atherosclerosis.


Descriptors :   macrophages , sclerosis , inflammation , cytokines , nanomedicine , cardiovascular diseases , nanoparticles


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE