Accession Number : AD1050261

Title :   Comparison of Bladder Directed and Pelvic Floor Therapy in Women With Interstitial Cystitis/Bladder Pain Syndrome

Descriptive Note : Technical Report,01 Sep 2016,31 Aug 2017


Personal Author(s) : Peters, Kenneth M

Full Text :

Report Date : 01 Sep 2017

Pagination or Media Count : 13

Abstract : Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating constellation of symptoms including urinary urgency, frequency, and pain related to the bladder, which predominantly affects women. Although symptoms appear to be bladder related, there has been little solid evidence linking IC/BPS with a dysfunctional bladder epithelium unless ulcers are present. There is growing evidence that the bladder may actually be an innocent bystander in a more diffuse syndrome with a complex interplay of various systems/factors. It is our objective to assess the role of the pelvic floor muscles as a major contributor to pelvic pain and voiding dysfunction in adult women with IC/BPS symptoms. During Year 1, we finalized the study protocol, trained all investigators, built and tested the research database, obtained IRB and HRPO approval, and enrolled our first subject. However, enrollment during Year 1 was hampered by a national shortage of one of the medications that are used for bladder instillations (bladder focused therapy), thus we have only randomized 1 of 128 total women (64 in each treatment arm). Although the supply of medication is still not widely available, we have obtained a limited supply and as of August,2017, have resumed study recruitment and enrollment.

Descriptors :   BLADDER(URINARY) , urinary tract , pain , ulcers , biological markers

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE