Accession Number : AD1050249


Title :   Acute and Delayed Systemic Treatment with Cannabinoid Receptor 2 Agonists to Prevent or Treat/Reverse Osteoporosis in a Mouse Model of SCI


Descriptive Note : Technical Report,01 Aug 2016,31 Jul 2017


Corporate Author : University of Mississippi Medical Center Jackson United States


Personal Author(s) : Grill, Raymond J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050249.pdf


Report Date : 01 Aug 2017


Pagination or Media Count : 8


Abstract : The overall goal of this project is to determine whether a selective agonist for the cannabinoid-2 receptor, when systemically delivered, can prevent the onset of osteoporosis in mice when delivered during the acute phase of spinal cord injury or restore bone density when delivery is delayed until the late, chronic period of injury. During this first year, we have focused on aim 1; testing a range of CB2 agonist concentrations, delivered early but over a maximum of 40 days (longest time group). While we are still assessing bone densities (post-mortem), we noted that both the low and high doses of CB2 agonist appear to elicit neuropathic pain-like symptoms, resulting in the required early euthanasia of those subjects. As a result, we are focusing on the mid-range dose for all subsequent experiments. We have also begun Aim 2 by performing the spinal transection surgeries. These animals will require a 3 month period (to induce chronic stage) before initiation of CB2 agonist treatment.


Descriptors :   spinal cord , spinal injuries , bone diseases , pain


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE