Accession Number : AD1050214


Title :   Therapeutic Sleep for Traumatic Brain Injury


Descriptive Note : Technical Report,01 Jun 2016,31 May 2017


Corporate Author : Northwestern University Evanston United States


Personal Author(s) : Allada, Ravi ; Van Alphen,Bart


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050214.pdf


Report Date : 01 Jun 2017


Pagination or Media Count : 8


Abstract : This proposal will test the hypothesis that correcting sleep disorders can have a therapeutic effect on Traumatic Brain Injury (TBI) The majority of TBI patients develop sleep disorders, a correlation that is extremely prevalent in military personnel. Here, we have developed a paradigm to induce TBI in Drosophila. TBI induction results in increased mortality, impaired climbing behavior, decreased/fragmented sleep and cell death. We also discovered a biphasic response in both impaired climbing behavior and altered gene expression in glia cells. We are currently testing whether sleep induction can restore these impairments.


Descriptors :   brain injuries , gene expression , trauma , sleep , sleep disorders , behavior , apoptosis


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Genetic Engineering and Molecular Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE