Accession Number : AD1050212


Title :   Tumor Slice Culture: A New Avatar in Personalized Oncology


Descriptive Note : Technical Report,01 Sep 2016,31 Aug 2017


Corporate Author : Institute for Systems Biology Seattle United States


Personal Author(s) : Tian, Qiang


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050212.pdf


Report Date : 01 Aug 2017


Pagination or Media Count : 10


Abstract : The goal of this research is to advance our ability to precisely tailor therapy for solid tumors based on an ex-vivo TSC platform as a novel avatar of personalized oncology. The age of genomic medicine has brought tremendous hope to cancer patients, but the way in which this information gets translated to a clinical decision represents a major knowledge gap facing the oncologist. We now know that tumors with the same genetic mutation can have highly variable responses to targeted therapy. The lack of a functional assay with a quick turnaround time is the Achilles heel of personalized oncology. The objective of this proposal is to establish a robust, efficient, reproducible platform to interrogate drug sensitivity and to correlate the results with clinical and molecular data.


Descriptors :   personalized medicine , oncology , neoplasms , cultures (biology) , mutations , drugs , sensitivity , metastasis , t lymphocytes , kinases , rna sequence analysis , drugs , statistical analysis , proteomics , genomics , inhibitors , inhibition


Distribution Statement : APPROVED FOR PUBLIC RELEASE