Accession Number : AD1050209


Title :   Tumor Slice Culture: A New Avatar in Personalized Oncology


Descriptive Note : Technical Report,01 Sep 2016,31 Aug 2017


Corporate Author : University of Washington Seattle United States


Personal Author(s) : Yeung, Raymond


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050209.pdf


Report Date : 01 Sep 2017


Pagination or Media Count : 10


Abstract : The project aims to improve our prediction of tumor response for patients with metastatic colorectal cancer (mCRC). Over the past year, we have been refining our tissue slice culture platform through standardization of protocol and modifications to culture conditions. We have developed a sensitivity index that allows for meaningful comparison between samples. Detailed analyses of tumor response to drugs are currently underway, along with advanced proteomic studies. Investigations using the slice culture to examine tumor response to immunotherapies have provided valuable insights towards novel strategies in the treatment of mCRC.


Descriptors :   colon cancer , drugs , sensitivity , immunotherapy , cultures (biology) , neoplasms , Oncology , personalized medicine , metastasis , proteomics , t lymphocytes , kinases , rna sequence analysis , genomics , inhibitors , inhibition


Subject Categories : Pharmacology
      Genetic Engineering and Molecular Biology
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE