Accession Number : AD1050188

Title :   Molecular and Cellular Determinants of Malignant Transformation in Pulmonary Premalignancy

Descriptive Note : Technical Report,01 Jul 2016,30 Jun 2017

Corporate Author : University of California, Los Angeles LOS ANGELES United States

Personal Author(s) : Krysan, Kostyantyn

Full Text :

Report Date : 01 Jul 2017

Pagination or Media Count : 11

Abstract : During the first funding period we completed Major Tasks 1 and 2. The areas of interest were identified in 41 lung cancer patient and isolated by LCM. Genomic DNA was isolated from these areas and whole exome sequencing was performed. The data has been analyzed and the progression-associated mutations, as well as premalignant- and malignant-specific mutations, were identified. The mutational data was analyzed in the pathway context. Based on the mutational analysis, neoantigens were identified.

Descriptors :   lung cancer , mutations , antigens , deoxyribonucleic acids , mutations , immunochemistry , lesions

Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE