Accession Number : AD1050188


Title :   Molecular and Cellular Determinants of Malignant Transformation in Pulmonary Premalignancy


Descriptive Note : Technical Report,01 Jul 2016,30 Jun 2017


Corporate Author : University of California, Los Angeles LOS ANGELES United States


Personal Author(s) : Krysan, Kostyantyn


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1050188.pdf


Report Date : 01 Jul 2017


Pagination or Media Count : 11


Abstract : During the first funding period we completed Major Tasks 1 and 2. The areas of interest were identified in 41 lung cancer patient and isolated by LCM. Genomic DNA was isolated from these areas and whole exome sequencing was performed. The data has been analyzed and the progression-associated mutations, as well as premalignant- and malignant-specific mutations, were identified. The mutational data was analyzed in the pathway context. Based on the mutational analysis, neoantigens were identified.


Descriptors :   lung cancer , mutations , antigens , deoxyribonucleic acids , mutations , immunochemistry , lesions


Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE