Accession Number : AD1049977


Title :   Reprograming the Metastatic Microenvironment to Combat Disease Recurrence


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Washington University St. Louis United States


Personal Author(s) : DeNardo, David G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1049977.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 12


Abstract : The prognosis for patients with widespread metastatic breast cancer is dismal and for many of these patients current tumor targeted therapies are not curative. Therefore, the development of new clinical approaches that are effective at preventing and/or treating metastatic BC is of paramount importance. One such promising approach is by reprograming the tissue microenvironments that provide safe harbor for disseminated tumor cells during adjuvant therapy. Our approach to destroying these safe harbors is to modulate the patients immune system. If we could reawaken the immune programs that destroy tumors, especially during adjuvant therapy when tumor cells are most vulnerable, we could truly eliminate residual disease and prevent metastatic recurrence. We believe we have found a way to accomplish this by inhibiting colony-stimulating factor-1 receptor (CSF1R) with clinically available therapeutics.


Descriptors :   clinical trials , tissues , immunotherapy , inhibition , t lymphocytes , biomedical research , drug therapy , macrophages , chemotherapy , myeloid cells , bone marrow , immune system , neoplasms , mononuclear phagocyte system , breast cancer , therapy , metastasis , bones


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE