Accession Number : AD1049937


Title :   Macrophage Efferocytosis and Prostate Cancer Bone Metastasis


Descriptive Note : Technical Report,15 Sep 2014,14 Dec 2017


Corporate Author : University of Michigan Ann Arbor United States


Personal Author(s) : Sinder,Benjamin P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1049937.pdf


Report Date : 01 Mar 2018


Pagination or Media Count : 44


Abstract : Findings identify macrophages and efferocytosis as a key mediator of prostate cancer skeletal metastasis and the bone microenvironment. Specifically, phagocytic macrophages and efferocytosis were found to be upregulated in the blood of patients with metastatic prostate cancer. Moreover, inhibiting phagocytic macrophages with the chemotherapeutic trabectedin reduced efferocytosis and prostate cancer tumor size in murine models. In addition, trabectedin inhibition of macrophages significantly altered macrophages and efferocytosis in the bone microenvironment a common site of prostate cancer metastasis. Trabectedin was further found to reduce bone mass and bone healing.


Descriptors :   Macrophages , bone and bones , prostate cancer , neoplasms , Metastasis , inhibition , chemotherapy


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE