Accession Number : AD1049865


Title :   Genetic Networks Activated by Blast Injury to the Eye


Descriptive Note : Technical Report,15 Jul 2012,14 Dec 2017


Corporate Author : Emory University Atlanta United States


Personal Author(s) : Geisert, Eldon E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1049865.pdf


Report Date : 01 Mar 2018


Pagination or Media Count : 173


Abstract : The present grant proposes to look at the effects of blast on the eye of the mouse looking at phenotypic changes in the eye and in the changes in gene expression following a 50psi blast. We are using these data to define biomarkers to predict the severity of the injury and to predict eventual outcomes. We have examined the phenotypic changes in the eye in the BXD strains before and 5 days after a 50psi blast and have observed no strain specific change in either the cornea or the IOP. We have completed the normal retina database containing 222 microarrays from 58 strains of mice. The data was presented in a publication in Molecular Vision. We have collected 213 retinas from 54 strains 5 days after a 50psi blast. The RNA from the retinas was processed and was run on microarray. The database is complete and the manuscript describing the results is published in Frontiers in Genetics. We have found two good markers for retinal injury: SOX11 involved in the abortive regeneration response and POU6F2 which marks reginal ganglion cells that are very susceptible to injury. We continue to examine the involvement of the immune system in the response of the retina to injury.


Descriptors :   eye , retinal diseases , eye diseases , genetics , gene expression , retina , blast injuries , gentic markers , cornea , lymphocytes , proteins , biological factors , ophthalmology


Subject Categories : Weapons Effects(biological)
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE