Accession Number : AD1049169


Title :   TBI-Induced Formation of Toxic Tau and Its Biochemical Similarities to Tau in AD Brains


Descriptive Note : Technical Report,15 Sep 2016,14 Sep 2017


Corporate Author : Columbia University in the City of New York New York United States


Personal Author(s) : Arancio, Ottavio


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1049169.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 14


Abstract : The goal of the current study is to demonstrate that blast-induced traumatic brain injury (TBI) and Alzheimer's disease(AD) lead to similar biochemical changes in tau that increase its toxicity and contribute to cognitive and electrophysiological impairments. Specifically we will test the hypothesis that 1) blast-induced TBI leads to the production of a toxic form of tau that contributes to cognitive and electrophysiological impairments; 2) the formation of soluble tau aggregates contributes to cognitive impairments associated with both blast-exposure and AD; 3) an increase in tau phosphorylation contributes to cognitive impairments associated with both blast-exposure and AD. During the last year we have completed experiments related to the first point of the hypothesis, and started working on the second point. Specifically, we have found that the presence of tau is necessary for a preparation from shockwave-exposed mice to reduce1) memory including contextual fear memory and spatial memory, and 2) long-term potentiation, a type of synaptic plasticity thought to underlie learning. We have also performed a dose response curve for the toxic effect of blasted tau onto memory and LTP.


Descriptors :   brain injuries , military medicine , blast injuries , ALZHEIMER DISEASE , cognitive impairment , memory


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE