Accession Number : AD1049166


Title :   Therapeutic Strategies Against Cyclin E1 Amplified Ovarian Cancers


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Dana-Farber Cancer Institute Boston United States


Personal Author(s) : Chowdhury, Dipanjan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1049166.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 17


Abstract : Approximately 20% of high grade serous ovarian cancers harbor Cyclin E1 (CCNE1) amplification and are associated with poor outcome and inferior responsiveness to standard platinum chemotherapy. Given their intrinsic resistance to platinum, management of CCNE1- amplified ovarian cancers is challenging. In this research, we evaluate three novel strategies against CCNE1-amplified ovarian cancers that address different aspects of CCNE1 biology. In the first aim, based on our preliminary data, we hypothesize that HSP90-inhibitors may be effective against CCNE1-amplified ovarian tumors because they suppress HR, downregulate BRCA1, and downregulate CCNE1. In the second aim, based on our preliminary data and the fact that RB functions downstream of cyclin E, we hypothesize that inhibition of FOXM1 and RB interaction is an effective approach for targeting CCNE1-amplified ovarian tumors. Specifically, suppression of FOXM1/RB interaction will lead to enhancement of RB/E2F interaction and suppression of E2F-dependent oncogenic activity resulting in activity against CCNE1-amplified cells. In the third aim, we hypothesize that miR-1255b, miR-148b*, and miR-193b* may be effective against CCNE1-amplified ovarian tumors in combination with platinum and PARPis. Potential mechanisms for this effect include suppression of HR and downregulation of BRCA1, RAD51 and BRCA2 that are relevant for CCNE1-amplified ovarian tumors which are dependent on hyperactive HR and are sensitive to suppression of BRCA1.


Descriptors :   Ovarian Cancer , ribonucleic acids , proteins , inhbitors , genes , neoplasms


Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE