Accession Number : AD1048533

Title :   Novel Models to Study Effect of High-Altitude Hypoxic Exposure and Placental Insufficiency on Fetal Oxygen Metabolism and Congenital Heart Defects

Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author : University of Maryland, Baltimore Baltimore United States

Personal Author(s) : Fisher, Steven

Full Text :

Report Date : 01 Oct 2017

Pagination or Media Count : 14

Abstract : The idea for this proposal is that acute high altitude hypoxic exposure early in pregnancy during a critical period of organogenesis may critically reduce O2 transport to the fetus thereby causing Congenital Heart Defects in at-risk pregnancies. The first objective was to use a novel reporter of O2 concentrations, the ODDLuc mouse, to determine the dose-response relationship between hypoxia and reduced O2 delivery to the fetus. The second objective was to develop a novel mouse model of placental insufficiency to examine how maternal-fetal and gene-environment interactions may influence the effect of hypoxia on the developing heart.

Descriptors :   high altitude , hypoxia , pregnancy , placenta , CONGENITAL HEART DEFECTS , genes , exposure (physiology) , metabolism

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE