Accession Number : AD1048533


Title :   Novel Models to Study Effect of High-Altitude Hypoxic Exposure and Placental Insufficiency on Fetal Oxygen Metabolism and Congenital Heart Defects


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : University of Maryland, Baltimore Baltimore United States


Personal Author(s) : Fisher, Steven


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1048533.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 14


Abstract : The idea for this proposal is that acute high altitude hypoxic exposure early in pregnancy during a critical period of organogenesis may critically reduce O2 transport to the fetus thereby causing Congenital Heart Defects in at-risk pregnancies. The first objective was to use a novel reporter of O2 concentrations, the ODDLuc mouse, to determine the dose-response relationship between hypoxia and reduced O2 delivery to the fetus. The second objective was to develop a novel mouse model of placental insufficiency to examine how maternal-fetal and gene-environment interactions may influence the effect of hypoxia on the developing heart.


Descriptors :   high altitude , hypoxia , pregnancy , placenta , CONGENITAL HEART DEFECTS , genes , exposure (physiology) , metabolism


Subject Categories : Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE