Accession Number : AD1048529


Title :   Understanding the Connection Between Traumatic Brain Injury and Alzheimer's Disease: A Population-Based Medical Record Review Analysis


Descriptive Note : Technical Report,15 Sep 2016,14 Sep 2017


Corporate Author : Mayo Clinic Rochester United States


Personal Author(s) : Brown, Allen W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1048529.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 11


Abstract : Purpose: The most accurate and reliable study design to determine whether the occurrence of TBI increases risk for the development of Alzheimers disease and related disorders (ADRD) is to identify incident TBI events by medical record review within a defined population and classify each by injury severity, identify matched referents within that same population, and follow both cohorts over time to observe incidence rates of ADRD. Scope: Compared to other study designs, our approach significantly reduces the methodological problems of referral and recall bias, and selective survival, which have limited the scientific communitys ability to determine whether TBI is indeed associated with an increased risk of ADRD. There are no published reports of a population-based analysis matching TBI cases, identified by medical record review and classified by injury severity into 3 strata, to population-based referents with non-head trauma. This is particularly important as non-head trauma may also increase the risk of ADRD. Major Findings: 5,430 records of individuals (78% of total) that include 7,565 code dates have been reviewed, yielding 1,428 confirmed cases (yield rate of 26%). 1274 cases (89%) have been matched to their population-based controls.


Descriptors :   epidemiology , dementia , brain injuries , trauma , Parkinsons disease , Alzheimer disease , statistical analysis


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE