Accession Number : AD1048475


Title :   Effects of Radiation on the Microbiota and Intestinal Inflammatory Disease


Descriptive Note : Technical Report,31 Aug 2016,30 Aug 2017


Corporate Author : Cedar-Sinai Medical Center Los Angeles United States


Personal Author(s) : Shiao, Stephen ; Underhill,David


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1048475.pdf


Report Date : 01 Sep 2017


Pagination or Media Count : 18


Abstract : In this annual report (covering initiating and collaborating PI projects) we report the completion of experiments investigating the effect of inflammatory stimuli and focal irradiation of mice on the bacterial and fungal microbiota. We previously identified substantial changes in intestinal microbial communities induced by intestinal radiation exposure. Currently, we demonstrate that these changes correlate with increased sensitivity to inflammatory stimuli. As outlined in the project proposal, we are now in the midst of experiments aimed a evaluating the effects of radiation-induced changes in the microbiota on intestinal susceptibility to inflammatory disease.


Descriptors :   colitis , cancer , radiation effects , inflammation , exposure (physiology)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE