Accession Number : AD1048282

Title :   Flexible Regenerative Nanoelectronics for Advanced Peripheral Neural Interfaces

Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author : University of Texas at Austin Austin United States

Personal Author(s) : Baker ,Aaron B ; Xie,Chong

Full Text :

Report Date : 01 Oct 2017

Pagination or Media Count : 20

Abstract : The overall objective of the proposed research is to develop a set of technologies to enable peripheral neural electrodes that have a high-density contact array, ultra-flexibility, and spatially defined biomaterials that promote neurovascular regeneration. The resulted regenerative neural electrode will be capable of selective interfacing and promote the ingrowth of neural and vascular tissues, which result in a seamless integration of peripheral nerves, vessels and electrode. We proposed the following related specific tasks to create advanced neural interfaces: Task 1. Design and fabrication of high-density ultra-flexible mesh electrodes. Task 2. Create and optimize patternable materials that can specifically induce neurovascular regeneration to stabilize electrode-nerve interaction. Task 3. Construct nerve guidance scaffolds comprising of embedded ultra-flexible mesh electrodes with defined pathways for neurogenesis/angiogenesis and test these scaffolds in a mouse subcutaneous implantation model and a rat sciatic nerve gap model.

Descriptors :   nanoelectronics , electrodes , regenerative medicine , biological materials , fabrication , sciatic nerve , assays

Subject Categories : Medicine and Medical Research
      Electrical and Electronic Equipment
      Miscellaneous Materials

Distribution Statement : APPROVED FOR PUBLIC RELEASE