Accession Number : AD1048276


Title :   Prazosin for Prophylaxis of Chronic Post Traumatic Headaches in OEF/OIF/OND Service Members and Veterans with Mild TBI


Descriptive Note : Technical Report,30 Sep 2016,29 Sep 2017


Corporate Author : Seattle Institute for Biomedical and Clinical Research Seattle United States


Personal Author(s) : Raskind, Murray


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1048276.pdf


Report Date : 01 Oct 2017


Pagination or Media Count : 8


Abstract : Headaches following combat-related mild traumatic brain injury (mTBI) are common, can be refractory to standard therapies, and may persist and worsen to become a debilitating chronic pain syndrome. The purpose of the proposed study is to evaluate the centrally acting alpha-1adrenoreceptor antagonist drug prazosin as a prophylactic treatment for chronic posttraumatic headache. The impetus for this study comes from a large open-label case series in Iraq and Afghanistan Veterans with mTBI and posttraumatic headaches and data from a placebo-controlled trial evaluating use of prazosin for PTSD in Iraq and Afghanistan active-duty Service Members that found beneficial effect of prazosin for decreasing the frequency and severity of headaches, in addition to decreasing PTSD-related symptoms and improving the quality of sleep. The objectives of this study will be accomplished by conducting a randomized placebo controlled double blind trial of prazosin vs placebo in 160 Iraq/Afghanistan active-duty Service Members and Veterans with persistent PTHAs.


Descriptors :   BRAIN INJURIES , MILITARY PERSONNEL , ACTIVE DUTY , MILITARY MEDICINE , PAIN MANAGEMENT , VETERANS HEALTH , DRUG THERAPY , CLINICAL TRIALS , HEADACHE DISORDERS , TRAUMATIC STRESS DISORDER


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE